Company description
Base excision repair (BER) corrects small base lesions that do not significantly distort the DNA helix structure. It is initiated by a DNA glycosylase that recognizes and removes the damaged base, leaving an abasic site which is further processed by short-patch repair or long-patch repair. Short-patch repair or long-patch repair largely uses different proteins to complete BER. BER may take place in nuclei or mitochondria, largely using different isoforms of proteins or genetically distant proteins.
